Target
Ras-related protein Rab-7a
Ligand
BDBM54558
Substrate
n/a
Meas. Tech.
Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54558
Synonyms:
1-[4-(2,5-dimethylphenyl)-1-piperazinyl]-2-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]ethanone | 1-[4-(2,5-dimethylphenyl)piperazin-1-yl]-2-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]ethanone | 1-[4-(2,5-dimethylphenyl)piperazino]-2-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]ethanone | KUC103369N | UNM-0000306079 | cid_20900764
Type:
Small organic molecule
Emp. Form.:
C23H26N4O3
Mol. Mass.:
406.4775
SMILES:
COc1ccc(cc1)-c1noc(CC(=O)N2CCN(CC2)c2cc(C)ccc2C)n1
Structure:
Search PDB for entries with ligand similarity: