Reaction Details
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GTPase KRas [1-37]
Ligand
BDBM50218889
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant
EC50
30000±n/a nM
Comments
Extracted from aid = 2043 and tid = 2
Citation
PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant PubChem Bioassay (2009)[AID] More Info.:
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Homo sapiens (Human)
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
Inhibitor
Name:
BDBM50218889
Synonyms:
7-chloroindirubin | CHEMBL243777 | cid_11847137
Type:
Small organic molecule
Emp. Form.:
C16H9ClN2O2
Mol. Mass.:
296.708
SMILES:
Clc1cccc2C(C(=O)Nc12)=C1Nc2ccccc2C1=O |w:11.13|
Structure:
