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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM54657
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant
EC50
30000±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM54657
Synonyms:
4-[3-(4-methoxyphenyl)-5-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-2-yl]benzenesulfonamide | 4-[5-(4-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]-2-pyrazolin-1-yl]benzenesulfonamide | KUC103436N | UNM-0000306155 | cid_44143710
Type:
Small organic molecule
Emp. Form.:
C23H20F3N3O3S
Mol. Mass.:
475.483
SMILES:
COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1cccc(c1)C(F)(F)F |c:11|
Structure:
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