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Target
Orexin receptor type 2
Ligand
BDBM101886
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
Temperature
310.15±n/a K
IC50
20±n/a nM
Comments
extracted
Citation
 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Thiazole orexin receptor antagonists US Patent  US9695163 Publication Date 7/4/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM101886
Synonyms:
US9695163, 22
Type:
Small organic molecule
Emp. Form.:
C22H26FN5O2S
Mol. Mass.:
443.538
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)c1nc(c(C)s1)C(C)(C)O |r|
Structure:
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