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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM101901
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
Temperature
310.15±n/a K
IC50
700±n/a nM
Comments
extracted
Citation
 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Thiazole orexin receptor antagonists US Patent  US9695163 Publication Date 7/4/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM101901
Synonyms:
US9695163, 27
Type:
Small organic molecule
Emp. Form.:
C22H26N4O2S2
Mol. Mass.:
442.597
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1nc(c(C)s1)C(C)(C)O |r|
Structure:
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