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Target
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Ligand
BDBM267937
Substrate
n/a
Meas. Tech.
Fluorescence based hOGA assay
pH
7±n/a
Temperature
298.15±n/a K
Ki
5.40±n/a nM
Comments
extracted
Citation
 Kaul, R; McEachern, EJ; Vocadlo, DJ; Zhou, Y; Liu, K; Selnick, HG; Wei, Z; Mu, C; Wang, Y; Wang, X Selective glycosidase inhibitors and uses thereof US Patent  US9718854 Publication Date 8/1/2017 
Target
Name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Synonyms:
2-keto-4-hydroxyglutarate aldolase | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial | C10orf65 | DHDPS-like protein | DHDPSL | Dihydrodipicolinate synthase-like, mitochondrial | HOGA1 | HOGA1_HUMAN | Probable KHG-aldolase | Protein 569272
Type:
PROTEIN
Mol. Mass.:
35253.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_461876
Residue:
327
Sequence:
MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPVDAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVCALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGGPCRAPLQELSPAEEEALRMDFTSNGWL
  
Inhibitor
Name:
BDBM267937
Synonyms:
(3aR,5R,6S,7R,7aR)-2-(ethylamino)- 5-((isopropylamino)methyl)-5,6,7,7a- tetrahydro-3aH-pyrano[3,2-d]thiazole- 6,7-diol | US9718854, 18
Type:
Small organic molecule
Emp. Form.:
C12H23N3O3S
Mol. Mass.:
289.394
SMILES:
CCNC1=N[C@H]2[C@H](O[C@H](CNC(C)C)[C@@H](O)[C@@H]2O)S1 |r,t:3|
Structure:
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