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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Ligand
BDBM54717
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL
EC50
45470±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL PubChem Bioassay (2009)[AID] 
Target
Name:
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:
B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:
Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:
26053.63
Organism:
Homo sapiens (Human)
Description:
gi_510901
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM54717
Synonyms:
4-bromanyl-2-[(E)-3-(2,3-dimethoxyphenyl)prop-2-enoyl]-7-(methylamino)cycloheptan-1-one | 4-bromo-2-[(E)-3-(2,3-dimethoxyphenyl)-1-oxoprop-2-enyl]-7-(methylamino)-1-cycloheptanone | 4-bromo-2-[(E)-3-(2,3-dimethoxyphenyl)acryloyl]-7-(methylamino)cycloheptanone | 4-bromo-2-[(E)-3-(2,3-dimethoxyphenyl)prop-2-enoyl]-7-(methylamino)cycloheptan-1-one | UNM-0000306221 | cid_44203220
Type:
Small organic molecule
Emp. Form.:
C19H24BrNO4
Mol. Mass.:
410.302
SMILES:
CNC1CCC(Br)CC(C(=O)C=Cc2cccc(OC)c2OC)C1=O |w:11.10|
Structure:
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