Reaction Details Report a problem with these data
Target
Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM54739
Substrate
n/a
Meas. Tech.
uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay
IC50
3950±n/a nM
Citation
 PubChem, PC uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay PubChem Bioassay (2009)[AID] 
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
  
Inhibitor
Name:
BDBM54739
Synonyms:
3-[1-(4-fluorophenyl)tetrazol-5-yl]sulfanyl-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[[1-(4-fluorophenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[[1-(4-fluorophenyl)-5-tetrazolyl]thio]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[[1-(4-fluorophenyl)tetrazol-5-yl]thio]-1-(4-methoxyphenyl)pyrrolidine-2,5-quinone | 3-{[1-(4-fluorophenyl)-1H-tetrazol-5-yl]thio}-1-(4-methoxyphenyl)-2,5-pyrrolidinedione | MLS000663719 | SMR000293005 | cid_2945197
Type:
Small organic molecule
Emp. Form.:
C18H14FN5O3S
Mol. Mass.:
399.399
SMILES:
COc1ccc(cc1)-n1c(O)cc(Sc2nnnn2-c2ccc(F)cc2)c1O
Structure:
Search PDB for entries with ligand similarity: