BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetKappa-type opioid receptor
LigandBDBM54807
Substrate/Competitorn/a
Meas. Tech.HTS Image-Based Screen for Selective Antagonists of the KOR Receptor
IC50 3856±393 nM
Citation PubChem, PC HTS Image-Based Screen for Selective Antagonists of the KOR Receptor PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Kappa-type opioid receptor
Name:Opioid receptors; mu/kappa/delta
Synonyms:K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | kappa opioid receptor (KOR)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42648.76
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from HEK-293 cells stably expressing KOP receptors.
Residue:380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM54807
NameBDBM54807
Synonyms:4-(2,5-dimethoxyphenyl)-N-[(Z)-3-indolylidenemethyl]-2-(2-methoxyethylimino)-3-thiazolamine | 4-(2,5-dimethoxyphenyl)-N-[(Z)-indol-3-ylidenemethyl]-2-(2-methoxyethylimino)-1,3-thiazol-3-amine | MLS000375345 | SMR000254598 | [4-(2,5-dimethoxyphenyl)-2-(2-methoxyethylimino)-4-thiazolin-3-yl]-[(Z)-indol-3-ylidenemethyl]amine | cid_6508436
TypeSmall organic molecule
Emp. Form.C23H24N4O3S
Mol. Mass.436.527
SMILESCOCCN=c1scc(-c2cc(OC)ccc2OC)n1N=Cc1c[nH]c2ccccc12 |w:20.21,4.3|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a