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Target
Streptokinase A
Ligand
BDBM54844
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression
EC50
1606±1196 nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM54844
Synonyms:
3-amino-5-(2,6-dimethylphenyl)imino-4-(morpholine-4-carbonyl)-N-(m-tolyl)-2H-thiophene-2-carboxamide | 3-amino-5-(2,6-dimethylphenyl)imino-N-(3-methylphenyl)-4-(morpholine-4-carbonyl)-2H-thiophene-2-carboxamide | 3-amino-5-(2,6-dimethylphenyl)imino-N-(3-methylphenyl)-4-[4-morpholinyl(oxo)methyl]-2H-thiophene-2-carboxamide | 3-azanyl-5-(2,6-dimethylphenyl)imino-N-(3-methylphenyl)-4-morpholin-4-ylcarbonyl-2H-thiophene-2-carboxamide | BRD-A24985936-001-04-2 | cid_4571353
Type:
Small organic molecule
Emp. Form.:
C25H28N4O3S
Mol. Mass.:
464.58
SMILES:
Cc1cccc(NC(=O)C2=C(N)C(C(=O)N3CCOCC3)\C(S2)=N\c2c(C)cccc2C)c1 |c:9|
Structure:
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