Reaction Details Report a problem with these data
Target
Core protein
Ligand
BDBM40675
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high-throughput dose response assay to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization.
IC50
>49751±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high-throughput dose response assay to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization. PubChem Bioassay (2009)[AID] 
Target
Name:
Core protein
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14237.71
Organism:
Hepatitis C virus
Description:
gi_83779224
Residue:
126
Sequence:
MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKDQRTTGKSWGKPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPNDPRHRSRNVGKVIDTL
  
Inhibitor
Name:
BDBM40675
Synonyms:
2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-(3-ethoxy-4-hydroxybenzylidene)-5-phenyl-2,4-dihydro-3H-pyrazol-3-one | 2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-[(E)-(3-ethoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]-5-phenyl-1H-pyrazol-3-one | 2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-[(E)-(3-ethoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-5-phenyl-1H-pyrazol-3-one | 2-[4-(4-bromophenyl)-2-thiazolyl]-4-[(E)-(3-ethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-5-phenyl-1H-pyrazol-3-one | 2-[4-(4-bromophenyl)thiazol-2-yl]-4-[(E)-(3-ethoxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-5-phenyl-3-pyrazolin-3-one | MLS000530455 | SMR000135433 | cid_6509369
Type:
Small organic molecule
Emp. Form.:
C27H20BrN3O3S
Mol. Mass.:
546.435
SMILES:
CCOC1=CC(=Cc2c([nH]n(-c3nc(cs3)-c3ccc(Br)cc3)c2=O)-c2ccccc2)C=CC1=O |w:6.6,c:35,t:3|
Structure:
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