Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM47246
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3).
IC50
5548±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3). PubChem Bioassay (2009)[AID] 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM47246
Synonyms:
(4E)-4-[(5-naphthalen-1-ylsulfanylfuran-2-yl)methylidene]-1-phenyl-pyrazolidine-3,5-dione | (4E)-4-[(5-naphthalen-1-ylsulfanylfuran-2-yl)methylidene]-1-phenylpyrazolidine-3,5-dione | (4E)-4-[[5-(1-naphthalenylthio)-2-furanyl]methylidene]-1-phenylpyrazolidine-3,5-dione | (4E)-4-[[5-(1-naphthylthio)-2-furyl]methylene]-1-phenyl-pyrazolidine-3,5-quinone | (4E)-4-{[5-(1-naphthylthio)-2-furyl]methylene}-1-phenylpyrazolidine-3,5-dione | MLS000582439 | SMR000206425 | cid_12004598
Type:
Small organic molecule
Emp. Form.:
C24H16N2O3S
Mol. Mass.:
412.46
SMILES:
O=C1NN(C(=O)\C1=C\c1ccc(Sc2cccc3ccccc23)o1)c1ccccc1
Structure:
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