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Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM268439
Substrate
n/a
Meas. Tech.
Nuclear receptor ROR-gamma
Temperature
298.15±n/a K
EC50
3.00±n/a nM
Comments
extracted
Citation
 Fauber, B; Gobbi, A Keto-imidazopyridine derivatives as RORc modulators US Patent  US9550771 Publication Date 1/24/2017 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM268439
Synonyms:
4-[3-(2- cyclopropylbenzoyl)imidazo[1,5- a]pyridin-1-yl]-2-hydroxy- benzoic acid | US9550771, Example 38
Type:
Small organic molecule
Emp. Form.:
C24H18N2O4
Mol. Mass.:
398.4107
SMILES:
OC(=O)c1ccc(cc1O)-c1nc(C(=O)c2ccccc2C2CC2)n2ccccc12
Structure:
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