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Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM268450
Substrate
n/a
Meas. Tech.
Nuclear receptor ROR-gamma
Temperature
298.15±n/a K
EC50
29.0±n/a nM
Comments
extracted
Citation
 Fauber, B; Gobbi, A Keto-imidazopyridine derivatives as RORc modulators US Patent  US9550771 Publication Date 1/24/2017 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM268450
Synonyms:
(3S,4R)-1-[3-(2-chloro-6- cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid (RACEMATE) | US9550771, Example 49 | US9550771, Example 51
Type:
Small organic molecule
Emp. Form.:
C23H22ClN3O4
Mol. Mass.:
439.891
SMILES:
O[C@@H]1CN(CC[C@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12 |r|
Structure:
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