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Target
M18 aspartyl aminopeptidase
Ligand
BDBM55123
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).
IC50
1691±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). PubChem Bioassay (2009)[AID] 
Target
Name:
M18 aspartyl aminopeptidase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
65642.43
Organism:
Plasmodium falciparum 3D7
Description:
gi_23505220
Residue:
570
Sequence:
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKENRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHTWFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIKPIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLDKNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFELCLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITNDINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEIYGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIKRTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIAAVHDVFFLIKGVFAFYTYYNQVLSTCVHDK
  
Inhibitor
Name:
BDBM55123
Synonyms:
(4E)-2-hydroxy-4-[4-(2-methyl-5-nitro-phenyl)-5-phenyl-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one | (4E)-2-hydroxy-4-[4-(2-methyl-5-nitrophenyl)-5-phenyl-1,3-dihydroimidazol-2-ylidene]-1-cyclohexa-2,5-dienone | (4E)-2-hydroxy-4-[4-(2-methyl-5-nitrophenyl)-5-phenyl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one | (4E)-4-[4-(2-methyl-5-nitro-phenyl)-5-phenyl-1,3-dihydroimidazol-2-ylidene]-2-oxidanyl-cyclohexa-2,5-dien-1-one | 4-[5-(2-Methyl-5-nitro-phenyl)-4-phenyl-1H-imidazol-2-yl]-benzene-1,2-diol | MLS000523372 | SMR000123350 | cid_6098488
Type:
Small organic molecule
Emp. Form.:
C22H17N3O4
Mol. Mass.:
387.3881
SMILES:
Cc1ccc(cc1-c1[nH+]c([nH]c1-c1ccccc1)-[c-]1ccc(=O)c(O)c1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: