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Target
M18 aspartyl aminopeptidase
Ligand
BDBM55158
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).
IC50
1011±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). PubChem Bioassay (2009)[AID] 
Target
Name:
M18 aspartyl aminopeptidase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
65642.43
Organism:
Plasmodium falciparum 3D7
Description:
gi_23505220
Residue:
570
Sequence:
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKENRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHTWFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIKPIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLDKNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFELCLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITNDINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEIYGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIKRTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIAAVHDVFFLIKGVFAFYTYYNQVLSTCVHDK
  
Inhibitor
Name:
BDBM55158
Synonyms:
(4Z)-2-hydroxy-4-[(1,2,4-triazol-1-ylamino)methylene]cyclohexa-2,5-dien-1-one | (4Z)-2-hydroxy-4-[(1,2,4-triazol-1-ylamino)methylidene]-1-cyclohexa-2,5-dienone | (4Z)-2-hydroxy-4-[(1,2,4-triazol-1-ylamino)methylidene]cyclohexa-2,5-dien-1-one | (4Z)-2-oxidanyl-4-[(1,2,4-triazol-1-ylamino)methylidene]cyclohexa-2,5-dien-1-one | 4-[(E)-(1H-1,2,4-triazol-1-ylimino)methyl]benzene-1,2-diol | MLS001194928 | SMR000554660 | cid_23734016
Type:
Small organic molecule
Emp. Form.:
C9H8N4O2
Mol. Mass.:
204.1854
SMILES:
Oc1ccc(C=Nn2cncn2)cc1O |w:6.6|
Structure:
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