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Target
Streptokinase A
Ligand
BDBM58653
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM58653
Synonyms:
MLS001074376 | N-[2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-5-(propylcarbamoyl)phenyl]-2-furamide | N-[2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-5-(propylcarbamoyl)phenyl]furan-2-carboxamide | N-[5-[oxo(propylamino)methyl]-2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)phenyl]-2-furancarboxamide | SMR000718491 | cid_24816792
Type:
Small organic molecule
Emp. Form.:
C28H30N4O4
Mol. Mass.:
486.5622
SMILES:
CCCNC(=O)c1ccc(N2CCC3(CC(=NO3)c3ccccc3)CC2)c(NC(=O)c2ccco2)c1 |c:15|
Structure:
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