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Target
Large T antigen
Ligand
BDBM59024
Substrate
n/a
Meas. Tech.
Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits
EC50
>50000±n/a nM
Citation
 PubChem, PC Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits PubChem Bioassay (2009)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEFSVPKTLQARFVKQIDFRAKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM59024
Synonyms:
(2E)-3-(3,5-dimethoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)-2-(1H-pyridin-2-ylidene)propanenitrile | (2E)-3-(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)-2-(1H-pyridin-2-ylidene)propanenitrile | (2E)-3-(3,5-dimethoxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2-(1H-pyridin-2-ylidene)propanenitrile | (2E)-3-(4-keto-3,5-dimethoxy-cyclohexa-2,5-dien-1-ylidene)-2-(1H-pyridin-2-ylidene)propionitrile | MLS000759671 | SMR000369423 | cid_6516058
Type:
Small organic molecule
Emp. Form.:
C16H14N2O3
Mol. Mass.:
282.294
SMILES:
COc1cc(C=C(C#N)c2ccccn2)cc(OC)c1O |w:5.4|
Structure:
Search PDB for entries with ligand similarity: