Reaction Details Report a problem with these data
Target
G1/S-specific cyclin-E1
Ligand
BDBM50319624
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
2.3e+2±n/a nM
Citation
 McInnes, C; Wang, S; Anderson, S; O'Boyle, J; Jackson, W; Kontopidis, G; Meades, C; Mezna, M; Thomas, M; Wood, G; Lane, DP; Fischer, PM Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem Biol 11:525-34 (2004) [PubMed]  Article 
Target
Name:
G1/S-specific cyclin-E1
Synonyms:
CCNE | CCNE1 | CCNE1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
47073.17
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
410
Sequence:
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
  
Inhibitor
Name:
BDBM50319624
Synonyms:
Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl)benzene-1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C15H15N5S
Mol. Mass.:
297.378
SMILES:
Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(N)cc2)n1
Structure:
Search PDB for entries with ligand similarity: