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Target
Cyclin-dependent kinase 5
Ligand
BDBM59199
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay of Tau Phosphorylation
IC50
1.70e+4±n/a nM
Citation
 Ahn, JS; Radhakrishnan, ML; Mapelli, M; Choi, S; Tidor, B; Cuny, GD; Musacchio, A; Yeh, LA; Kosik, KS Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol 12:811-23 (2005) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM59199
Synonyms:
2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.0
Type:
Small organic molecule
Emp. Form.:
C23H24ClN3O
Mol. Mass.:
393.909
SMILES:
Clc1cc2CN(COc2c2ncccc12)C1CCN(Cc2ccccc2)CC1
Structure:
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