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Target
Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N]
Ligand
BDBM1437
Substrate
(poly)rC:(oligo)dG
Meas. Tech.
HIV-1 RT Assay
pH
8.2±n/a
IC50
33400±n/a nM
Citation
 Williams, TM; Ciccarone, TM; MacTough, SC; Rooney, CS; Balani, SK; Condra, JH; Emini, EA; Goldman, ME; Greenlee, WJ; Kauffman, LR 5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase. J Med Chem 36:1291-4 (1993) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N]
Synonyms:
EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (K103N)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [588-1147,K690N]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (K103N) Chain A | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
64471.33
Organism:
Human immunodeficiency virus type 1
Description:
P04585[588-1147,K690N]
Residue:
560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVL
  
Component 2
Name:
Gag-Pol polyprotein [588-1027,K690N]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (K103N) Chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
51280.01
Organism:
Human immunodeficiency virus type 1
Description:
P04585[588-1027,K690N]
Residue:
440
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYNLEKEPIVGAETF
  
Inhibitor
Name:
BDBM1437
Synonyms:
5-methoxyindole-2-carboxylic acid [N -[3-(aminoethyl)pyridin-2-yl]piperazide] | BHAP deriv. | CHEMBL280527 | CHEMBL7264 | N-ethyl-2-{4-[(5-methoxy-1H-indol-2-yl)carbonyl]piperazin-1-yl}pyridin-3-amine | U-87201E | bis(heteroaryl)piperazine analog
Type:
Small organic molecule
Emp. Form.:
C21H25N5O2
Mol. Mass.:
379.4555
SMILES:
CCNc1cccnc1N1CCN(CC1)C(=O)c1cc2cc(OC)ccc2[nH]1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
(poly)rC:(oligo)dG
Synonyms:
n/a
Type:
RNA-DNA duplex
Mol. Mass.:
358.43
Organism:
n/a
Description:
The incorporation of Tritium-labeled [3H]dGTP onto a (poly)rC:(oligo)dG template:primer.
Residue:
3
Sequence:
NA