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TargetCyclin-dependent kinase 2
LigandBDBM8037
Substrate/Competitorn/a
Meas. Tech.In Vitro Inhibition
IC50 6.50e+3± 0 nM
Citation Kontopidis, GMcInnes, CPandalaneni, SRMcNae, IGibson, DMezna, MThomas, MWood, GWang, SWalkinshaw, MDFischer, PM Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design. Chem Biol13:201-11 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2/G1/S-specific cyclin-D1
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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  Blast E-value cutoff:
BDBM8037
NameBDBM8037
Synonyms:2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 8 | 4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamine | 4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine | 4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine, 1 | CS12
TypeSmall organic molecule
Emp. Form.C9H10N4S
Mol. Mass.206.268
SMILESCc1nc(C)c(s1)-c1ccnc(N)n1
Structure
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