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Target
Cyclin-dependent kinase 2
Ligand
BDBM8066
Substrate
n/a
Meas. Tech.
In Vitro Inhibition
IC50
2.2e+2±n/a nM
Citation
 Kontopidis, G; McInnes, C; Pandalaneni, SR; McNae, I; Gibson, D; Mezna, M; Thomas, M; Wood, G; Wang, S; Walkinshaw, MD; Fischer, PM Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design. Chem Biol 13:201-11 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM8066
Synonyms:
2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine, 3 | 4-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine | N-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl]N,N-dimethylbenzene-1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C17H19N5S
Mol. Mass.:
325.431
SMILES:
CN(C)c1ccc(Nc2nccc(n2)-c2sc(C)nc2C)cc1
Structure:
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