Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM59290
Substrate
n/a
Meas. Tech.
uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay
EC50
100000±n/a nM
Citation
 PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM59290
Synonyms:
(1Z)-1-[(2-quinolin-8-ylhydrazinyl)methylidene]naphthalen-2-one | (1Z)-1-[(8-quinolinylhydrazo)methylidene]-2-naphthalenone | (1Z)-1-[[N'-(8-quinolyl)hydrazino]methylene]naphthalen-2-one | 2-hydroxy-1-naphthaldehyde 8-quinolinylhydrazone | MLS000576620 | SMR000185294 | cid_5720514
Type:
Small organic molecule
Emp. Form.:
C20H15N3O
Mol. Mass.:
313.3526
SMILES:
Oc1ccc2ccccc2c1CN=Nc1cccc2cccnc12 |w:13.15|
Structure:
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