Reaction Details Report a problem with these data
Target
M17 leucyl aminopeptidase
Ligand
BDBM60057
Substrate
n/a
Meas. Tech.
Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP)
IC50
1450±n/a nM
Citation
 PubChem, PC Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP) PubChem Bioassay (2009)[AID] 
Target
Name:
M17 leucyl aminopeptidase
Synonyms:
leucine aminopeptidase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67834.32
Organism:
Plasmodium falciparum 3D7
Description:
gi_124809582
Residue:
605
Sequence:
MYFSSLCKFLPISEKEKIYLNIVKKRFCKSNIYYNNNNNNIINYNKRGLKFYPFCNNLKKNINFVNINNKKGINFHSINKERKMASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKNVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILNSSKTSNEPVWWLPIINEYRATLNSKYADINNISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLNDAL
  
Inhibitor
Name:
BDBM60057
Synonyms:
MLS000698754 | N-(1,2-dihydro-5-acenaphthylenyl)-2-[(4-hydroxy-6-oxo-1-phenyl-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetamide | N-(1,2-dihydroacenaphthylen-5-yl)-2-(6-hydroxy-4-oxo-1-phenylpyrimidin-2-yl)sulfanylacetamide | N-(1,2-dihydroacenaphthylen-5-yl)-2-(6-oxidanyl-4-oxidanylidene-1-phenyl-pyrimidin-2-yl)sulfanyl-ethanamide | N-(1,2-dihydroacenaphthylen-5-yl)-2-[(6-hydroxy-4-oxo-1-phenyl-2-pyrimidinyl)thio]acetamide | N-acenaphthen-5-yl-2-[(6-hydroxy-4-keto-1-phenyl-pyrimidin-2-yl)thio]acetamide | SMR000226481 | cid_1208699
Type:
Small organic molecule
Emp. Form.:
C24H19N3O3S
Mol. Mass.:
429.491
SMILES:
Oc1cc(=O)n(c(SCC(=O)Nc2ccc3CCc4cccc2c34)n1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: