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Target
Kappa-type opioid receptor
Ligand
BDBM60217
Substrate
n/a
Meas. Tech.
uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay
IC50
980±n/a nM
Citation
 PubChem, PC uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay PubChem Bioassay (2009)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM60217
Synonyms:
1,2-dihydroimidazo[1,2-a]benzimidazol-3-yl-(1-piazthiol-4-ylsulfonyl-4-piperidyl)methanone | 1-{[1-(2,1,3-benzothiadiazol-4-ylsulfonyl)piperidin-4-yl]carbonyl}-2,3-dihydro-1H-imidazo[1,2-a]benzimidazole | MLS000091773 | SMR000026320 | [1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-4-piperidinyl]-(1,2-dihydroimidazo[1,2-a]benzimidazol-3-yl)methanone | [1-(2,1,3-benzothiadiazol-4-ylsulfonyl)piperidin-4-yl]-(1,2-dihydroimidazo[1,2-a]benzimidazol-3-yl)methanone | cid_3240530
Type:
Small organic molecule
Emp. Form.:
C21H20N6O3S2
Mol. Mass.:
468.552
SMILES:
O=C(C1CCN(CC1)S(=O)(=O)c1cccc2nsnc12)N1CCn2c1nc1ccccc21
Structure:
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