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Target
Kappa-type opioid receptor
Ligand
BDBM54802
Substrate
n/a
Meas. Tech.
uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay
IC50
2820±n/a nM
Citation
 PubChem, PC uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay PubChem Bioassay (2009)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM54802
Synonyms:
2-(N-(4-methoxyphenyl)sulfonylanilino)-N-(4-morpholin-4-ylsulfonylphenyl)acetamide | 2-(N-(4-methoxyphenyl)sulfonylanilino)-N-(4-morpholinosulfonylphenyl)acetamide | 2-(N-(4-methoxyphenyl)sulfonylanilino)-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide | 2-[(4-methoxyphenyl)sulfonyl-phenyl-amino]-N-(4-morpholin-4-ylsulfonylphenyl)ethanamide | MLS000581499 | N~2~-[(4-methoxyphenyl)sulfonyl]-N~1~-[4-(4-morpholinylsulfonyl)phenyl]-N~2~-phenylglycinamide | SMR000200126 | cid_2958242
Type:
Small organic molecule
Emp. Form.:
C25H27N3O7S2
Mol. Mass.:
545.628
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: