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Target
Kappa-type opioid receptor
Ligand
BDBM60264
Substrate
n/a
Meas. Tech.
uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay
IC50
3750±n/a nM
Citation
 PubChem, PC uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay PubChem Bioassay (2009)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM60264
Synonyms:
2-(4-Bromo-phenyl)-quinoline-4-carboxylic acid [1-pyridin-2-yl-meth-(E)-ylidene]-hydrazide | 2-(4-bromophenyl)-N-(2-pyridinylmethylideneamino)-4-quinolinecarboxamide | 2-(4-bromophenyl)-N-(2-pyridylmethyleneamino)cinchoninamide | 2-(4-bromophenyl)-N-(pyridin-2-ylmethylideneamino)quinoline-4-carboxamide | MLS000767800 | SMR000430129 | cid_1970900
Type:
Small organic molecule
Emp. Form.:
C22H15BrN4O
Mol. Mass.:
431.285
SMILES:
Brc1ccc(cc1)-c1cc(C(=O)NN=Cc2ccccn2)c2ccccc2n1
Structure:
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