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Target
Kappa-type opioid receptor
Ligand
BDBM54528
Substrate
n/a
Meas. Tech.
uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay
IC50
3540±n/a nM
Citation
 PubChem, PC uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay PubChem Bioassay (2009)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM54528
Synonyms:
5-bromanyl-2-oxidanyl-N-(1-pyridin-2-ylethylideneamino)benzamide | 5-bromo-2-hydroxy-N-(1-pyridin-2-ylethylideneamino)benzamide | 5-bromo-2-hydroxy-N-[1-(2-pyridinyl)ethylideneamino]benzamide | 5-bromo-2-hydroxy-N-[1-(2-pyridyl)ethylideneamino]benzamide | MLS001224732 | SMR000679069 | cid_872878
Type:
Small organic molecule
Emp. Form.:
C14H12BrN3O2
Mol. Mass.:
334.168
SMILES:
CC(=NNC(=O)c1cc(Br)ccc1O)c1ccccn1 |w:2.2|
Structure:
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