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Target
Large T antigen
Ligand
BDBM60360
Substrate
n/a
Meas. Tech.
Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents
IC50
100000±n/a nM
Citation
 PubChem, PC Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents PubChem Bioassay (2010)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEFSVPKTLQARFVKQIDFRAKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM60360
Synonyms:
(5Z)-5-[[4-(diethylamino)anilino]methylene]-1-(o-tolyl)barbituric acid | (5Z)-5-[[4-(diethylamino)anilino]methylidene]-1-(2-methylphenyl)-1,3-diazinane-2,4,6-trione | (5Z)-5-[[[4-(diethylamino)phenyl]amino]methylidene]-1-(2-methylphenyl)-1,3-diazinane-2,4,6-trione | MLS000078218 | SMR000057847 | cid_5389151
Type:
Small organic molecule
Emp. Form.:
C22H24N4O3
Mol. Mass.:
392.451
SMILES:
CCN(CC)c1ccc(cc1)N=Cc1c(O)n(-c2ccccc2C)c(=O)[nH]c1=O |w:11.11,(4.41,6.16,;5.75,5.39,;5.75,3.85,;4.41,3.08,;3.08,3.85,;7.08,3.08,;7.08,1.54,;8.41,.77,;9.75,1.54,;9.75,3.08,;8.41,3.85,;11.08,.77,;12.42,1.54,;13.75,.77,;13.75,-.77,;12.42,-1.54,;15.08,-1.54,;15.08,-3.08,;16.42,-3.85,;16.42,-5.39,;15.08,-6.16,;13.75,-5.39,;13.75,-3.85,;12.42,-3.08,;16.42,-.77,;17.75,-1.54,;16.42,.77,;15.08,1.54,;15.08,3.08,)|
Structure:
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