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Target
SUMO-activating enzyme subunit 1
Ligand
BDBM61205
Substrate
n/a
Meas. Tech.
uHTS HTRF assay for identification of inhibitors of SUMOylation
IC50
3790±n/a nM
Citation
 PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM61205
Synonyms:
1,8-bis(azanyl)-6-methoxy-3-pyrrolidin-1-yl-2,7-naphthyridine-4-carbonitrile;ethanoic acid | 1,8-diamino-6-methoxy-3-pyrrolidino-2,7-naphthyridine-4-carbonitrile | MLS001007001 | SMR000349800 | acetic acid;1,8-diamino-6-methoxy-3-(1-pyrrolidinyl)-2,7-naphthyridine-4-carbonitrile | acetic acid;1,8-diamino-6-methoxy-3-pyrrolidin-1-yl-2,7-naphthyridine-4-carbonitrile | acetic acid;1,8-diamino-6-methoxy-3-pyrrolidino-2,7-naphthyridine-4-carbonitrile | cid_16196095
Type:
Small organic molecule
Emp. Form.:
C14H16N6O
Mol. Mass.:
284.3164
SMILES:
COc1cc2c(C#N)c(nc(N)c2c(N)n1)N1CCCC1
Structure:
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