Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM30811
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
75100±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM30811
Synonyms:
1-methyl-3-phenyl-2,5,6,7,8,9-hexahydroimidaz[1,2-a]azepin-1-ium-3-ol;iodide | 1-methyl-3-phenyl-2,5,6,7,8,9-hexahydroimidazo[1,2-a]azepin-1-ium-3-ol;iodide | MLS000048587 | SMR000060502 | cid_2998813
Type:
Small organic molecule
Emp. Form.:
C15H21N2O
Mol. Mass.:
245.3395
SMILES:
CN1CC(O)(c2ccccc2)[N+]2=C1CCCCC2 |c:12|
Structure:
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