Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61286
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
12265±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61286
Synonyms:
2-(1-ethylbenzimidazol-2-yl)sulfanyl-N-[[(Z)-3-(furan-2-yl)prop-2-enylidene]amino]acetamide | 2-(1-ethylbenzimidazol-2-yl)sulfanyl-N-[[(Z)-3-(furan-2-yl)prop-2-enylidene]amino]ethanamide | 2-[(1-ethyl-1H-benzimidazol-2-yl)thio]-N'-[(1E,2Z)-3-(2-furyl)prop-2-enylidene]acetohydrazide | 2-[(1-ethyl-2-benzimidazolyl)thio]-N-[[(Z)-3-(2-furanyl)prop-2-enylidene]amino]acetamide | 2-[(1-ethylbenzimidazol-2-yl)thio]-N-[[(Z)-3-(2-furyl)prop-2-enylidene]amino]acetamide | MLS000584782 | SMR000203745 | cid_12005014
Type:
Small organic molecule
Emp. Form.:
C18H18N4O2S
Mol. Mass.:
354.426
SMILES:
CCn1c(SCC(=O)NN=C\C=C/c2ccco2)nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: