Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM50398
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
2660±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM50398
Synonyms:
(4Z)-3-(4-nitrophenyl)-4-[(3-nitrophenyl)hydrazinylidene]-5-oxidanylidene-pyrazole-1-carbothioamide | (4Z)-3-(4-nitrophenyl)-4-[(3-nitrophenyl)hydrazinylidene]-5-oxo-1-pyrazolecarbothioamide | (4Z)-3-(4-nitrophenyl)-4-[(3-nitrophenyl)hydrazinylidene]-5-oxopyrazole-1-carbothioamide | (4Z)-5-keto-3-(4-nitrophenyl)-4-[(3-nitrophenyl)hydrazono]-2-pyrazoline-1-carbothioamide | MLS000713374 | SMR000272855 | cid_5756839
Type:
Small organic molecule
Emp. Form.:
C16H11N7O5S
Mol. Mass.:
413.367
SMILES:
NC(=S)n1[n-]c(c(N=[NH+]c2cccc(c2)[N+]([O-])=O)c1=O)-c1ccc(cc1)[N+]([O-])=O |w:7.6|
Structure:
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