Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61306
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
5430±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61306
Synonyms:
2-(1,5-dihydroxy-3,4-diketo-2-naphthyl)-3-methoxy-5-methyl-benzoic acid | 2-(1,5-dihydroxy-3,4-dioxo-2-naphthalenyl)-3-methoxy-5-methylbenzoic acid | 2-(1,5-dihydroxy-3,4-dioxonaphthalen-2-yl)-3-methoxy-5-methylbenzoic acid | 2-[1,5-bis(oxidanyl)-3,4-bis(oxidanylidene)naphthalen-2-yl]-3-methoxy-5-methyl-benzoic acid | MLS000877007 | SMR000440651 | cid_10360755
Type:
Small organic molecule
Emp. Form.:
C19H14O7
Mol. Mass.:
354.3103
SMILES:
COc1cc(C)cc(C(O)=O)c1C1C(=O)C(=O)c2c(O)cccc2C1=O
Structure:
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