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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61322
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
7250±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61322
Synonyms:
5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxidanylidene-3-piperidin-1-yl-propyl]-4-phenyl-chromen-2-one | 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxo-3-(1-piperidinyl)propyl]-4-phenyl-1-benzopyran-2-one | 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxo-3-piperidin-1-ylpropyl]-4-phenylchromen-2-one | 8-[3-keto-1-(4-methoxyphenyl)-3-piperidino-propyl]-5,7-dimethoxy-4-phenyl-coumarin | MLS000879461 | SMR000465526 | cid_16746331
Type:
Small organic molecule
Emp. Form.:
C32H33NO6
Mol. Mass.:
527.6075
SMILES:
COc1ccc(cc1)C(CC(=O)N1CCCCC1)c1c(OC)cc(OC)c2c(cc(=O)oc12)-c1ccccc1
Structure:
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