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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61371
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
11095±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61371
Synonyms:
3-[[2-[(E)-[1-[2-(4-methylanilino)-2-oxoethyl]-2,5-dioxo-4-imidazolidinylidene]methyl]phenoxy]methyl]benzoic acid | 3-[[2-[(E)-[1-[2-(4-methylanilino)-2-oxoethyl]-2,5-dioxoimidazolidin-4-ylidene]methyl]phenoxy]methyl]benzoic acid | 3-[[2-[(E)-[1-[2-[(4-methylphenyl)amino]-2-oxidanylidene-ethyl]-2,5-bis(oxidanylidene)imidazolidin-4-ylidene]methyl]phenoxy]methyl]benzoic acid | 3-[[2-[(E)-[2,5-diketo-1-[2-keto-2-(p-toluidino)ethyl]imidazolidin-4-ylidene]methyl]phenoxy]methyl]benzoic acid | MLS000947983 | SMR000620170 | cid_16468113
Type:
Small organic molecule
Emp. Form.:
C27H23N3O6
Mol. Mass.:
485.488
SMILES:
Cc1ccc(NC(=O)CN2C(=O)N\C(=C\c3ccccc3OCc3cccc(c3)C(O)=O)C2=O)cc1
Structure:
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