Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61307
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
9215±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61307
Synonyms:
4-Chloro-benzoic acid [1-[3-methoxy-4-(5-nitro-pyridin-2-yloxy)-phenyl]-meth-(Z)-ylidene]-hydrazide | 4-chloranyl-N-[[3-methoxy-4-(5-nitropyridin-2-yl)oxy-phenyl]methylideneamino]benzamide | 4-chloro-N-[[3-methoxy-4-(5-nitropyridin-2-yl)oxyphenyl]methylideneamino]benzamide | 4-chloro-N-[[3-methoxy-4-[(5-nitro-2-pyridinyl)oxy]phenyl]methylideneamino]benzamide | 4-chloro-N-[[3-methoxy-4-[(5-nitro-2-pyridyl)oxy]benzylidene]amino]benzamide | MLS000779575 | SMR000419758 | cid_4263693
Type:
Small organic molecule
Emp. Form.:
C20H15ClN4O5
Mol. Mass.:
426.81
SMILES:
COc1cc(\C=N\NC(=O)c2ccc(Cl)cc2)ccc1Oc1ccc(cn1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: