Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61236
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
100000±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61236
Synonyms:
2-{4-[(2-Hydroxy-benzoyl)-hydrazonomethyl]-2-methoxy-phenoxy}-N-phenyl-acetamide | MLS001212428 | N-[[3-methoxy-4-(2-oxidanylidene-2-phenylazanyl-ethoxy)phenyl]methylideneamino]-2-oxidanyl-benzamide | N-[[4-(2-anilino-2-keto-ethoxy)-3-methoxy-benzylidene]amino]-2-hydroxy-benzamide | N-[[4-(2-anilino-2-oxoethoxy)-3-methoxyphenyl]methylideneamino]-2-hydroxybenzamide | SMR000515267 | cid_1105530
Type:
Small organic molecule
Emp. Form.:
C23H21N3O5
Mol. Mass.:
419.4299
SMILES:
COc1cc(C=NNC(=O)c2ccccc2O)ccc1OCC(=O)Nc1ccccc1
Structure:
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