Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61391
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
3265±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61391
Synonyms:
2-chloranyl-N-ethyl-5-(4-ethylpiperazin-1-yl)sulfonyl-N-[2-[(4-methoxyphenyl)amino]-2-oxidanylidene-ethyl]benzamide | 2-chloro-N-ethyl-5-(4-ethylpiperazin-1-yl)sulfonyl-N-[2-(4-methoxyanilino)-2-oxoethyl]benzamide | 2-chloro-N-ethyl-5-(4-ethylpiperazino)sulfonyl-N-[2-keto-2-(p-anisidino)ethyl]benzamide | 2-chloro-N-ethyl-5-[(4-ethyl-1-piperazinyl)sulfonyl]-N-[2-(4-methoxyanilino)-2-oxoethyl]benzamide | MLS001080908 | SMR000713486 | cid_24856175
Type:
Small organic molecule
Emp. Form.:
C24H31ClN4O5S
Mol. Mass.:
523.045
SMILES:
CCN(CC(=O)Nc1ccc(OC)cc1)C(=O)c1cc(ccc1Cl)S(=O)(=O)N1CCN(CC)CC1
Structure:
Search PDB for entries with ligand similarity: