Target
Polyadenylate-binding protein 1
Ligand
BDBM61392
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
5825±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61392
Synonyms:
1-(3-chloro-4-methoxy-anilino)ethylidene-[2-[(4-chlorophenyl)sulfonylamino]ethyl]-methyl-ammonium;iodide | 1-(3-chloro-4-methoxyanilino)ethylidene-[2-[(4-chlorophenyl)sulfonylamino]ethyl]-methylammonium;iodide | 1-(3-chloro-4-methoxyanilino)ethylidene-[2-[(4-chlorophenyl)sulfonylamino]ethyl]-methylazanium;iodide | 1-[(3-chloranyl-4-methoxy-phenyl)amino]ethylidene-[2-[(4-chlorophenyl)sulfonylamino]ethyl]-methyl-azanium;iodide | 3-chloro-N-{(Z)-1-[(2-{[(4-chlorophenyl)sulfonyl]amino}ethyl)(methyl)amino]ethylidene}-4-methoxybenzenaminium iodide | MLS001165876 | SMR000672482 | cid_16413721
Type:
Small organic molecule
Emp. Form.:
C18H22Cl2N3O3S
Mol. Mass.:
431.356
SMILES:
COc1ccc(N\C(C)=[N+](/C)CCNS(=O)(=O)c2ccc(Cl)cc2)cc1Cl
Structure:
Search PDB for entries with ligand similarity: