Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM59743
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM59743
Synonyms:
MLS000114429 | N-[4-(diethylamino)phenyl]-2-[(4-keto-6-methyl-1H-pyrimidin-2-yl)thio]acetamide | N-[4-(diethylamino)phenyl]-2-[(6-methyl-4-oxidanylidene-1H-pyrimidin-2-yl)sulfanyl]ethanamide | N-[4-(diethylamino)phenyl]-2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide | N-[4-(diethylamino)phenyl]-2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]acetamide | SMR000091817 | cid_974977
Type:
Small organic molecule
Emp. Form.:
C17H22N4O2S
Mol. Mass.:
346.447
SMILES:
CCN(CC)c1ccc(NC(=O)CSc2nc(C)cc(=O)[nH]2)cc1
Structure:
Search PDB for entries with ligand similarity: