Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM59951
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
59331±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM59951
Synonyms:
4,5-Dimethoxy-2-[2-(3,5,8-trimethyl-quinolin-2-ylsulfanyl)-acetylamino]-benzoic acid | 4,5-dimethoxy-2-[2-(3,5,8-trimethylquinolin-2-yl)sulfanylethanoylamino]benzoic acid | 4,5-dimethoxy-2-[[1-oxo-2-[(3,5,8-trimethyl-2-quinolinyl)thio]ethyl]amino]benzoic acid | 4,5-dimethoxy-2-[[2-(3,5,8-trimethylquinolin-2-yl)sulfanylacetyl]amino]benzoic acid | 4,5-dimethoxy-2-[[2-[(3,5,8-trimethyl-2-quinolyl)thio]acetyl]amino]benzoic acid | MLS000548308 | SMR000170972 | cid_1176185
Type:
Small organic molecule
Emp. Form.:
C23H24N2O5S
Mol. Mass.:
440.512
SMILES:
COc1cc(NC(=O)CSc2nc3c(C)ccc(C)c3cc2C)c(cc1OC)C(O)=O
Structure:
Search PDB for entries with ligand similarity: