Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM60030
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM60030
Synonyms:
2-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-oxobutanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]thio]-3-keto-butyronitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]thio]-3-oxobutanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-4-[[5-[(2,4-dimethylphenyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-3-oxidanylidene-butanenitrile | MLS000392163 | SMR000261114 | cid_5683040
Type:
Small organic molecule
Emp. Form.:
C21H18N6OS2
Mol. Mass.:
434.537
SMILES:
Cc1ccc(Nc2nnc(SCC(=O)C(C#N)c3nc4ccccc4[nH]3)s2)c(C)c1
Structure:
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