Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM54099
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM54099
Synonyms:
5-(1-Acetyl-5-phenyl-pyrazolidin-3-ylidene)-1,3-dimethyl-pyrimidine-2,4,6-trione | 5-(1-acetyl-5-phenyl-3-pyrazolidinylidene)-1,3-dimethyl-1,3-diazinane-2,4,6-trione | 5-(1-acetyl-5-phenyl-pyrazolidin-3-ylidene)-1,3-dimethyl-barbituric acid | 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethyl-1,3-diazinane-2,4,6-trione | 5-(1-ethanoyl-5-phenyl-pyrazolidin-3-ylidene)-1,3-dimethyl-1,3-diazinane-2,4,6-trione | MLS000763011 | SMR000439472 | cid_6236645
Type:
Small organic molecule
Emp. Form.:
C17H18N4O4
Mol. Mass.:
342.3492
SMILES:
CN1C(=O)C(C2=NN(C(C2)c2ccccc2)C(C)=O)C(=O)N(C)C1=O |t:5|
Structure:
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