Reaction Details Report a problem with these data
Target
Free fatty acid receptor 2
Ligand
BDBM404238
Substrate
n/a
Meas. Tech.
BINDING ASSAY
EC50
600±n/a nM
Citation
 Hoveyda, HR; Schils, D; Zoute, L; Parcq, J Substituted pyrrolidines as G-protein coupled receptor 43 agonists US Patent  US10017468 Publication Date 7/10/2018 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM404238
Synonyms:
(2S,5R)-5-(2-chlorophenyl)-1-(1-(2-methoxy-4-(trifluoromethyl)phenyl)piperidine-4-carbonyl)pyrrolidine-2-carboxylic acid | US10017468, Compound 407 | US10781171, Compound 407 | US11072582, Compound 407
Type:
Small organic molecule
Emp. Form.:
C25H26ClF3N2O4
Mol. Mass.:
510.933
SMILES:
COc1cc(ccc1N1CCC(CC1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O)C(F)(F)F
Structure:
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