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TargetBcl-2-like protein 1
LigandBDBM31765
Substrate/Competitorn/a
Meas. Tech.Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50 53204±n/a nM
Citation PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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  Blast E-value cutoff:
BDBM31765
NameBDBM31765
Synonyms:MLS-0024020.0001 | N-(5-methyl-1,2-oxazol-3-yl)-2-thiophen-2-yl-ethanamide | N-(5-methyl-1,2-oxazol-3-yl)-2-thiophen-2-ylacetamide | N-(5-methyl-3-isoxazolyl)-2-thiophen-2-ylacetamide | N-(5-methylisoxazol-3-yl)-2-(2-thienyl)acetamide | cid_717599
TypeSmall organic molecule
Emp. Form.C10H10N2O2S
Mol. Mass.222.264
SMILESCc1cc(NC(=O)Cc2cccs2)no1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a