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Target
Bcl-2-like protein 1
Ligand
BDBM34475
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
108803±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM34475
Synonyms:
9-bromanyl-4-oxidanyl-6H-chromeno[2,3-b]indol-3-one | 9-bromo-4-hydroxy-6H-[1]benzopyrano[2,3-b]indol-3-one | 9-bromo-4-hydroxy-6H-chromen[2,3-b]indol-3-one | 9-bromo-4-hydroxy-6H-chromeno[2,3-b]indol-3-one | 9-bromochromeno[2,3-b]indole-3,4-diol | MLS000049296 | SMR000075134 | cid_976141
Type:
Small organic molecule
Emp. Form.:
C15H8BrNO3
Mol. Mass.:
330.133
SMILES:
Oc1c2oc3[nH]c4ccc(Br)cc4c3cc2ccc1=O
Structure:
Search PDB for entries with ligand similarity: