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Target
Bcl-2-like protein 1
Ligand
BDBM60527
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
12089±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM60527
Synonyms:
(5Z)-5-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-1-(3-chlorophenyl)-1,3-diazinane-2,4,6-trione | (5Z)-5-[[5-(1H-benzimidazol-2-ylthio)-2-furanyl]methylidene]-1-(3-chlorophenyl)-1,3-diazinane-2,4,6-trione | (5Z)-5-[[5-(1H-benzimidazol-2-ylthio)-2-furyl]methylene]-1-(3-chlorophenyl)barbituric acid | 5-[1-[5-(1H-Benzoimidazol-2-ylsulfanyl)-furan-2-yl]-meth-(Z)-ylidene]-1-(3-chloro-phenyl)-pyrimidine-2,4,6-trione | MLS000587247 | SMR000211287 | cid_1895189
Type:
Small organic molecule
Emp. Form.:
C22H13ClN4O4S
Mol. Mass.:
464.881
SMILES:
Clc1cccc(c1)N1C(=O)NC(=O)C(=Cc2ccc(Sc3nc4ccccc4[nH]3)o2)C1=O |w:14.15|
Structure:
Search PDB for entries with ligand similarity: