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TargetBcl-2-like protein 1
LigandBDBM61868
Substrate/Competitorn/a
Meas. Tech.Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50 27638±n/a nM
Citation PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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  Blast E-value cutoff:
BDBM61868
NameBDBM61868
Synonyms:5-[(3-carbazol-9-ylpropanoylhydrazinylidene)methyl]-4-(4-methylpyridin-1-ium-1-yl)-1,3-thiazol-2-olate | 5-[(3-carbazol-9-ylpropanoylhydrazono)methyl]-4-(4-methylpyridin-1-ium-1-yl)thiazol-2-olate | 5-[[[3-(9-carbazolyl)-1-oxopropyl]hydrazinylidene]methyl]-4-(4-methyl-1-pyridin-1-iumyl)-2-thiazololate | MLS001049385 | SMR000427303 | cid_1963735
TypeSmall organic molecule
Emp. Form.C25H21N5O2S
Mol. Mass.455.532
SMILESCc1cc[n+](cc1)-c1[n-]c(=O)sc1\C=N\NC(=O)CCn1c2ccccc2c2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a